{"id":19485,"date":"2021-04-05T02:34:00","date_gmt":"2021-04-05T01:34:00","guid":{"rendered":"https:\/\/catalinx.ro\/wordpress\/?p=19485"},"modified":"2021-04-09T09:15:37","modified_gmt":"2021-04-09T08:15:37","slug":"inlocuitori-pentru-invermectina-bamlanivimab-si-vir-7831","status":"publish","type":"post","link":"https:\/\/catalinx.ro\/wordpress\/?p=19485","title":{"rendered":"\u00cenlocuitori pentru ivermectin\u0103: Bamlanivimab si VIR-7831"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n\n<p>Dou\u0103 cuvinte noi.  Tot se bate lumea pe ivermectin antimalarie c\u0103 poate merge \u0219i ca antiviral \u0219i unii mor ca animalele \u00een urma folosirii lui, dou\u0103 parteneriate de companii au aplicat pentru licen\u021bierea a dou\u0103 noi tratamente antivirale care poate o s\u0103 ne ajute, dac\u0103 o s\u0103 avem bani de ele. M\u0103car or s\u0103 fie mai bune dec\u00e2t o frec\u021bie la pl\u0103m\u00e2n de lemn. <\/p>\n\n\n\n<p>Al doilea, <a href=\"https:\/\/www.genengnews.com\/covid-19-candidates\/vir-biotechnology-and-glaxosmithkline-gsk\/\">VIR-7831<\/a>, care este  cel mai recent, e un tratament cu anticorpi,  de la Vir Biotechnology  \u00een parteneriat cu GSK.  <a href=\"https:\/\/www.gsk.com\/en-gb\/media\/press-releases\/gsk-and-vir-biotechnology-announce-submission-of-emergency-use-authorization-request-to-fda-for-vir-7831-for-the-early-treatment-of-covid-19\/\">Au aplicat deja<\/a> pentru aprobare de urgen\u021b\u0103 \u00een US, aparent  reduc spitalizarea \u0219i moartea \u00een protec\u021bie de 85% &#8211; <strong>din testele lor<\/strong>.  Au publicat si <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2021.03.09.434607v1\">studiul<\/a>.  <\/p>\n\n\n\n<p>Aparent, rezultatele sunt mai modeste pentru tulpina din UK, aia e, dac\u0103 o ave\u021bi pe aia, tot ivercmentina e la putere. Glumesc, b\u0103!<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\"><p>As variant evolution is a natural part of SARS-CoV-2 biology and emerging live virus variants are not always readily accessible for testing, a vesicular stomatitis virus (VSV)-based pseudotyped virus system targeting Vero E6 cells was used to examine VIR-7831 and VIR-7832 neutralization of UK (B.1.1.7), South Africa (B.1.351) or Brazil (P.1) S. IC<sub>50<\/sub>&nbsp;shifts were &lt;1-fold for both antibodies against the B.1.351 and P.1 pseudotyped viruses <strong>while small IC<sub>50<\/sub>&nbsp;shifts were observed for the UK pseudotyped virus (2.30- and 2.50-fold, respectively) i<\/strong>ndicating that VIR-7831 and VIR-7832 retain activity against these spike variants (<strong><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2021.03.09.434607v1.full#F1\">Figure 1e<\/a>;&nbsp;<a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2021.03.09.434607v1.full#T1\">Table 1<\/a><\/strong>). Interestingly, antibody neutralization of B.1.1.7 pseudotyped virus did not reach 100% in this assay though recently published data on the S309 mAb against infectious B.1.1.7 showed that full neutralization was achieved<sup><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2021.03.09.434607v1.full#ref-30\">30<\/a><\/sup>.<strong>However, VIR-7831 achieved its lowest score against the U.K. variant, with a reduction in susceptibility of 2.3-fold following testing with 10 Spike sequence substitutions\u2014H69-, V70-, Y144-, N501Y, A570D, D614G, P681H, T716I, S982A, and D1118H.<\/strong><\/p><cite><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2021.03.09.434607v1.full\">citat din studiu<\/a>. <\/cite><\/blockquote>\n\n\n\n<p><strong>Bamlanivimab<\/strong> e deja aprobat<a href=\"https:\/\/www.fda.gov\/news-events\/press-announcements\/coronavirus-covid-19-update-fda-authorizes-monoclonal-antibody-treatment-covid-19\"> \u00een Statele Unite<\/a> din decembrie 2020, pentru tratamentul \u00eempotriva covid-ului, c\u0103 \u0219i ivermectina e, <strong>dar pentru altceva<\/strong>. <\/p>\n\n\n\n<p><a href=\"https:\/\/www.europeanpharmaceuticalreview.com\/news\/145550\/ema-concludes-review-of-lillys-covid-19-antibody-therapies-bamlanivimab-etesevimab\/\"><strong>EMA<\/strong><\/a>, fiind o t\u00e2rf\u0103 lene\u0219\u0103 c\u00e2nd vine treaba de autorizat medicamente, a f\u0103cut un evaluare <strong>pozitiv\u0103<\/strong> abia luna trecut\u0103 a <strong>Bamlanivimab<\/strong>-ului.  Ce e drept, e posibil c\u0103 nici Eli Lilly, producatorul, nu cred c\u0103 s-a gr\u0103bit s\u0103 cear aprobarea la vogonii de la EMA, c\u0103 \u0219i-a\u0219a nu se g\u0103se\u0219te pe toate drumurile \u0219i americanii au mai bani dec\u00e2t europenii. Cred eu. Dar acuma e recomandat de pus \u00een cocktailul de antivirale, a\u0219a c\u0103 haida, suna\u021bi-v\u0103 pilele de pe la farmacii s\u0103 v\u0103 caute d-\u0103stea bune, nu mai lua\u021bi hapuri de c\u00e2ini.<\/p>\n\n\n\n<p class=\"has-cyan-bluish-gray-background-color has-background\">Articolul \u0219i titlul \u0103sta sunt scrise pentru SEO, c\u0103 pro\u0219tilor n-ai cum s\u0103 le oferi \u0219tiin\u021b\u0103 altfel. Nici pe bani, nici pe degeaba, nici m\u0103car dac\u0103-i pl\u0103te\u0219ti. Ei se uit\u0103 la televizor \u0219i dau pe google, p\u00e2n\u0103 la primul rezultat. Probabil ar trebui s\u0103 \u0219i pl\u0103tesc articlul \u0103sta s\u0103 apar\u0103 primul \u00een google la <strong>ivermectin\u0103,<\/strong> dar o s\u0103-i mai d\u0103m \u0219i \u00een s\u0103r\u0103cie( nu pot s\u0103 zic pula mea , c\u0103 m\u0103 penalizeaz\u0103 google)  pe pro\u0219ti, c\u0103 dac\u0103 mai mor din ei nu ne deranjeaz\u0103 a\u0219a mult.  Sunt sigur c\u0103 pro\u0219tii nu o s\u0103 observe nici notele de pamflet din text, dar consider c\u0103 e mai bine dec\u00e2t nimic.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dou\u0103 cuvinte noi. Tot se bate lumea pe ivermectin antimalarie c\u0103 poate merge \u0219i ca antiviral \u0219i unii mor ca animalele \u00een urma folosirii lui,&hellip;<\/p>\n","protected":false},"author":2,"featured_media":19488,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[1207,6],"tags":[4368,3796,4366,4369,4367],"class_list":["post-19485","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cucultura","category-de-criza","tag-bag-invermectin-pana-mor","tag-covid-19","tag-inlocuitor-de-invermectina","tag-invermectina-tratament-covid","tag-nu-mai-luati-invermectin"],"views":2954,"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/catalinx.ro\/wordpress\/wp-content\/uploads\/2021\/04\/invermectina-inlocuitor.png","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p4Eq23-54h","jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/catalinx.ro\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/19485","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/catalinx.ro\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/catalinx.ro\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/catalinx.ro\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/catalinx.ro\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=19485"}],"version-history":[{"count":4,"href":"https:\/\/catalinx.ro\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/19485\/revisions"}],"predecessor-version":[{"id":19557,"href":"https:\/\/catalinx.ro\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/19485\/revisions\/19557"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/catalinx.ro\/wordpress\/index.php?rest_route=\/wp\/v2\/media\/19488"}],"wp:attachment":[{"href":"https:\/\/catalinx.ro\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=19485"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/catalinx.ro\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=19485"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/catalinx.ro\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=19485"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}